Immuno-Grade GPR20 Receptor Antibodies

GPR20 (G Protein-Coupled Receptor 20) is an orphan GPCR characterized by constitutive activity, leading to activation of Gi/o proteins and inhibition of intracellular cAMP production. Its endogenous ligand remains unidentified, but its signaling activity suggests roles in cellular regulation and homeostasis. GPR20 is expressed in various tissues including cardiac and gastrointestinal tissues. It is also detected in certain cancer cell types, including those of the gastrointestinal tract and gliomas. GPR20 has gained attention as a potential pharmacological target, particularly in oncology. Recent studies have implicated it in tumor growth and survival, especially in cancers such as diffuse gastric cancer. For more information on GPR20 pharmacology please refer to the IUPHAR database. For further reading refer to:

Davenport AP, Alexander SP, Sharman JL, Pawson AJ, Benson HE, Monaghan AE, Liew WC, Mpamhanga CP, Bonner TI, Neubig RR, Pin JP, Spedding M, Harmar AJ. International Union of Basic and Clinical Pharmacology. LXXXVIII. G protein-coupled receptor list: recommendations for new pairings with cognate ligands. Pharmacol Rev. 2013 May 17;65(3):967-86. doi: 10.1124/pr.112.007179. PMID: 23686350; PMCID: PMC3698937.

Alexander SP, Battey J, Benson HE, Benya RV, Bonner TI, Davenport AP, Dhanachandra Singh K, Eguchi S, Harmar A, Holliday N, Jensen RT, Karnik S, Kostenis E, Liew WC, Monaghan AE, Mpamhanga C, Neubig R, Pawson AJ, Pin JP, Sharman JL, Spedding M, Spindel E, Stoddart L, Storjohann L, Thomas WG, Tirupula K, Vanderheyden P. Class A Orphans in GtoPdb v.2023.1. IUPHAR/BPS Guide to Pharmacology CITE. 2023; 2023(1). Available from: https://doi.org/10.2218/gtopdb/F16/2023.1.