Immuno-Grade GPR27 Receptor Antibodies

GPR27 (G Protein-Coupled Receptor 27) is an orphan GPCR belonging to the SREB (Super Conserved Receptor Expressed in Brain) family, which includes receptors involved in neuroendocrine and metabolic regulation. Although its endogenous ligand has not been identified, GPR27 is thought to participate in signaling pathways that influence cellular metabolism and development. GPR27 is primarily expressed in the central nervous system, with notable expression in the hypothalamus, hippocampus, and cortex. It is also present in pancreatic islets, skeletal muscle, and adipose tissue, suggesting a potential role in glucose metabolism and energy homeostasis. GPR27 is under early investigation as a potential pharmacological target, especially in the context of metabolic disorders such as type 2 diabetes and obesity. Experimental studies have suggested that it may influence insulin secretion and glucose uptake, making it a candidate for therapeutic exploration. For more information on GPR27 pharmacology please refer to the IUPHAR database. For further reading refer to:

Davenport AP, Alexander SP, Sharman JL, Pawson AJ, Benson HE, Monaghan AE, Liew WC, Mpamhanga CP, Bonner TI, Neubig RR, Pin JP, Spedding M, Harmar AJ. International Union of Basic and Clinical Pharmacology. LXXXVIII. G protein-coupled receptor list: recommendations for new pairings with cognate ligands. Pharmacol Rev. 2013 May 17;65(3):967-86. doi: 10.1124/pr.112.007179. PMID: 23686350; PMCID: PMC3698937.

Alexander SP, Battey J, Benson HE, Benya RV, Bonner TI, Davenport AP, Dhanachandra Singh K, Eguchi S, Harmar A, Holliday N, Jensen RT, Karnik S, Kostenis E, Liew WC, Monaghan AE, Mpamhanga C, Neubig R, Pawson AJ, Pin JP, Sharman JL, Spedding M, Spindel E, Stoddart L, Storjohann L, Thomas WG, Tirupula K, Vanderheyden P. Class A Orphans in GtoPdb v.2023.1. IUPHAR/BPS Guide to Pharmacology CITE. 2023; 2023(1). Available from: https://doi.org/10.2218/gtopdb/F16/2023.1.