Immuno-Grade GPR87 Receptor Antibodies

GPR87 (G Protein-Coupled Receptor 87) is an orphan GPCR that has been proposed to respond to lysophosphatidic acid (LPA), a bioactive lipid involved in cell proliferation and survival. GPR87 plays roles in cell growth, stress response, and tumor biology. GPR87 is expressed in various tissues, with particularly high expression in epithelial cells and certain cancer types, including lung, bladder, pancreatic, and squamous cell carcinomas. It is also found in normal tissues such as the skin and lungs, but at lower levels. GPR87 is considered a promising pharmacological target, especially in oncology. Its upregulation in multiple cancers and role in tumor cell survival and proliferation make it a candidate for cancer therapy. Inhibition of GPR87 has shown anti-tumor effects in preclinical models, though selective modulators are still in early development. For more information on GPR84 pharmacology please refer to the IUPHAR database. For further reading refer to:

Davenport AP, Alexander SP, Sharman JL, Pawson AJ, Benson HE, Monaghan AE, Liew WC, Mpamhanga CP, Bonner TI, Neubig RR, Pin JP, Spedding M, Harmar AJ. International Union of Basic and Clinical Pharmacology. LXXXVIII. G protein-coupled receptor list: recommendations for new pairings with cognate ligands. Pharmacol Rev. 2013 May 17;65(3):967-86. doi: 10.1124/pr.112.007179. PMID: 23686350; PMCID: PMC3698937.

Alexander SP, Battey J, Benson HE, Benya RV, Bonner TI, Davenport AP, Dhanachandra Singh K, Eguchi S, Harmar A, Holliday N, Jensen RT, Karnik S, Kostenis E, Liew WC, Monaghan AE, Mpamhanga C, Neubig R, Pawson AJ, Pin JP, Sharman JL, Spedding M, Spindel E, Stoddart L, Storjohann L, Thomas WG, Tirupula K, Vanderheyden P. Class A Orphans in GtoPdb v.2023.1. IUPHAR/BPS Guide to Pharmacology CITE. 2023; 2023(1). Available from: https://doi.org/10.2218/gtopdb/F16/2023.1.