Chemerin Receptor Phosphorylation Assays

The chemoattractant protein and adipokine, chemerin, has been shown to be the endogenous ligand for both chemerin family receptors. Chemerin 1 receptor was the founding family member, and when GPR1 was de-orphanised it was re-named Chemerin 2 receptor. Chemerin1 is also activated by the lipid-derived, anti-inflammatory ligand resolvin E1 (RvE1), which is formed via the sequential metabolism of EPA by aspirin-modified cyclooxygenase and lipoxygenase. In addition, two GPCRs for resolvin D1 (RvD1) have been identified: FPR2/ALX, the lipoxin A4 receptor, and GPR32, an orphan receptor.

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pS345/pS346-CMKLR1 Phosphorylation Assay Kit

The pS345/pS346-CMKLR1 Phosphorylation Assay Kit allows determination of CMKLR1 Phosphorylation in 96-well plates without the need for Western blot analysis.

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Details

For more information on chemokine receptor pharmacology please refer to the IUPHAR database. For further reading refer to:

Kennedy AJ, Davenport AP. International Union of Basic and Clinical Pharmacology CIII: Chemerin Receptors CMKLR1 (Chemerin1) and GPR1 (Chemerin2) Nomenclature, Pharmacology, and Function. Pharmacol Rev. 2018 Jan;70(1):174-196. doi: 10.1124/pr.116.013177. Epub 2017 Dec 26. PMID: 29279348

Davenport AP, Monaghan AE. Chemerin receptors (version 2019.3) in the IUPHAR/BPS Guide to Pharmacology Database. IUPHAR/BPS Guide to Pharmacology CITE. 2019; 2019(3). Available from: https://doi.org/10.2218/gtopdb/F338/2021.3.

For more information on chemokine receptor pharmacology please refer to the IUPHAR database. For further reading refer to: Kennedy AJ, Davenport AP. International Union of Basic... read more »

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Chemerin Receptor Phosphorylation Assays

For more information on chemokine receptor pharmacology please refer to the IUPHAR database. For further reading refer to: