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Immuno-Grade Atypical Chemokine Receptor 4 Antibodies

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Immunohistochemical identification of Atypical Chemokine Receptor 4 in human spleen.
ACKR4 (IHC-grade), Atypical Chemokine Receptor...
The ACKR4 receptor antibody is directed against the distal end of the carboxyl-terminal tail of human Atypical Chemokine Receptor 4. It can be used to detect total ACKR4 receptors in Western blots independent of phosphorylation. The...
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The atypical chemokine receptor 4 (ACKR4) acts as chemokine scavenger (also known as chemokine decoy receptor). ACKR4 can sequester a broad range of chemokines including CCL2, CCL8, CCL13, CCL19, CCL21 and CCL25. Chemokine-binding does not activate G-protein-mediated signal transduction but instead induces beta-arrestin recruitment, leading to ligand internalization. ACKR4 plays an important role in controlling the migration of immune and cancer cells that express chemokine receptors CCR7 and CCR9, by reducing the availability of CCL19, CCL21, and CCL25 through internalization. ACKR4 negatively regulates CXCR3-induced chemotaxis. ACKR4 also regulates T-cell development in the thymus.

The atypical chemokine receptor 4 (ACKR4) acts as chemokine scavenger (also known as chemokine decoy receptor). ACKR4 can sequester a broad range of chemokines including CCL2, CCL8, CCL13, CCL19,... read more »
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Immuno-Grade Atypical Chemokine Receptor 4 Antibodies

The atypical chemokine receptor 4 (ACKR4) acts as chemokine scavenger (also known as chemokine decoy receptor). ACKR4 can sequester a broad range of chemokines including CCL2, CCL8, CCL13, CCL19, CCL21 and CCL25. Chemokine-binding does not activate G-protein-mediated signal transduction but instead induces beta-arrestin recruitment, leading to ligand internalization. ACKR4 plays an important role in controlling the migration of immune and cancer cells that express chemokine receptors CCR7 and CCR9, by reducing the availability of CCL19, CCL21, and CCL25 through internalization. ACKR4 negatively regulates CXCR3-induced chemotaxis. ACKR4 also regulates T-cell development in the thymus.

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