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GPR62 Receptor Antibodies

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Validation of the GPR62 Receptor in transfected HEK293 cells
GPR62 (non-phospho), G protein-coupled...
The non-phospho-GPR62 receptor antibody is directed against the distal end of the carboxyl-terminal tail of human GPR62. It can be used to detect total GPR62 receptors in Western blots independent of phosphorylation. The GPR62 antibody...
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GPR62 (G Protein-Coupled Receptor 62) is an orphan GPCR that has been implicated in various physiological processes, although its exact endogenous ligand remains unidentified. It is thought to play a role in neurodevelopment and neurological functions. GPR62 is primarily expressed in the central nervous system, particularly in areas such as the striatum and cortex, which are involved in movement control, cognition, and emotion regulation. It is also found in other tissues, though its expression outside the brain is relatively low. While GPR62 is not yet a major focus for drug development, its expression in the brain and its potential involvement in dopaminergic signaling suggest it could be relevant in the context of neuropsychiatric disorders such as Parkinson's disease, schizophrenia, and depression. GPR62 is enriched in oligodendrocytes. For more information on GPR62 pharmacology please refer to the IUPHAR database. For further reading refer to: 

Davenport AP, Alexander SP, Sharman JL, Pawson AJ, Benson HE, Monaghan AE, Liew WC, Mpamhanga CP, Bonner TI, Neubig RR, Pin JP, Spedding M, Harmar AJ. International Union of Basic and Clinical Pharmacology. LXXXVIII. G protein-coupled receptor list: recommendations for new pairings with cognate ligands. Pharmacol Rev. 2013 May 17;65(3):967-86. doi: 10.1124/pr.112.007179. PMID: 23686350; PMCID: PMC3698937.

Alexander SP, Battey J, Benson HE, Benya RV, Bonner TI, Davenport AP, Dhanachandra Singh K, Eguchi S, Harmar A, Holliday N, Jensen RT, Karnik S, Kostenis E, Liew WC, Monaghan AE, Mpamhanga C, Neubig R, Pawson AJ, Pin JP, Sharman JL, Spedding M, Spindel E, Stoddart L, Storjohann L, Thomas WG, Tirupula K, Vanderheyden P. Class A Orphans in GtoPdb v.2023.1. IUPHAR/BPS Guide to Pharmacology CITE. 2023; 2023(1). Available from: https://doi.org/10.2218/gtopdb/F16/2023.1.

GPR62 (G Protein-Coupled Receptor 62) is an orphan GPCR that has been implicated in various physiological processes, although its exact endogenous ligand remains unidentified. It is thought to... read more »
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GPR62 Receptor Antibodies

GPR62 (G Protein-Coupled Receptor 62) is an orphan GPCR that has been implicated in various physiological processes, although its exact endogenous ligand remains unidentified. It is thought to play a role in neurodevelopment and neurological functions. GPR62 is primarily expressed in the central nervous system, particularly in areas such as the striatum and cortex, which are involved in movement control, cognition, and emotion regulation. It is also found in other tissues, though its expression outside the brain is relatively low. While GPR62 is not yet a major focus for drug development, its expression in the brain and its potential involvement in dopaminergic signaling suggest it could be relevant in the context of neuropsychiatric disorders such as Parkinson's disease, schizophrenia, and depression. GPR62 is enriched in oligodendrocytes. For more information on GPR62 pharmacology please refer to the IUPHAR database. For further reading refer to: 

Davenport AP, Alexander SP, Sharman JL, Pawson AJ, Benson HE, Monaghan AE, Liew WC, Mpamhanga CP, Bonner TI, Neubig RR, Pin JP, Spedding M, Harmar AJ. International Union of Basic and Clinical Pharmacology. LXXXVIII. G protein-coupled receptor list: recommendations for new pairings with cognate ligands. Pharmacol Rev. 2013 May 17;65(3):967-86. doi: 10.1124/pr.112.007179. PMID: 23686350; PMCID: PMC3698937.

Alexander SP, Battey J, Benson HE, Benya RV, Bonner TI, Davenport AP, Dhanachandra Singh K, Eguchi S, Harmar A, Holliday N, Jensen RT, Karnik S, Kostenis E, Liew WC, Monaghan AE, Mpamhanga C, Neubig R, Pawson AJ, Pin JP, Sharman JL, Spedding M, Spindel E, Stoddart L, Storjohann L, Thomas WG, Tirupula K, Vanderheyden P. Class A Orphans in GtoPdb v.2023.1. IUPHAR/BPS Guide to Pharmacology CITE. 2023; 2023(1). Available from: https://doi.org/10.2218/gtopdb/F16/2023.1.

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