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GPR26 Receptor Antibodies

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Validation of the GPR26 Receptor in transfected HEK293 cells
GPR26 (non-phospho), G protein-coupled Receptor...
The non-phospho-GPR26 receptor antibody is directed against the distal end of the carboxyl-terminal tail of human GPR26. It can be used to detect total GPR26 receptors in Western blots independent of phosphorylation. The GPR26 antibody...
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GPR26 (G Protein-Coupled Receptor 26) is an orphan GPCR with constitutive activity, primarily coupling to Gs proteins to increase intracellular cAMP levels. Its endogenous ligand has not been identified, but it is thought to play roles in central nervous system functions. GPR26 is predominantly expressed in the brain, especially in regions such as the cerebral cortex, hippocampus, and amygdala, which are involved in mood regulation, learning, and memory. This brain-specific expression pattern points to a potential role in neuropsychiatric functions. GPR26 is being investigated as a potential pharmacological target in neurological and psychiatric disorders, including anxiety, depression, and epilepsy. Preclinical studies have shown that modulation of GPR26 expression or activity can influence mood and seizure susceptibility. While no selective ligands or drugs are currently available, its expression profile and constitutive signaling make it a candidate for future therapeutic exploration in CNS-related diseases. For more information on GPR26 pharmacology please refer to the IUPHAR database. For further reading refer to:

Davenport AP, Alexander SP, Sharman JL, Pawson AJ, Benson HE, Monaghan AE, Liew WC, Mpamhanga CP, Bonner TI, Neubig RR, Pin JP, Spedding M, Harmar AJ. International Union of Basic and Clinical Pharmacology. LXXXVIII. G protein-coupled receptor list: recommendations for new pairings with cognate ligands. Pharmacol Rev. 2013 May 17;65(3):967-86. doi: 10.1124/pr.112.007179. PMID: 23686350; PMCID: PMC3698937.

Alexander SP, Battey J, Benson HE, Benya RV, Bonner TI, Davenport AP, Dhanachandra Singh K, Eguchi S, Harmar A, Holliday N, Jensen RT, Karnik S, Kostenis E, Liew WC, Monaghan AE, Mpamhanga C, Neubig R, Pawson AJ, Pin JP, Sharman JL, Spedding M, Spindel E, Stoddart L, Storjohann L, Thomas WG, Tirupula K, Vanderheyden P. Class A Orphans in GtoPdb v.2023.1. IUPHAR/BPS Guide to Pharmacology CITE. 2023; 2023(1). Available from: https://doi.org/10.2218/gtopdb/F16/2023.1.

GPR26 (G Protein-Coupled Receptor 26) is an orphan GPCR with constitutive activity, primarily coupling to Gs proteins to increase intracellular cAMP levels. Its endogenous ligand has not been... read more »
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GPR26 Receptor Antibodies

GPR26 (G Protein-Coupled Receptor 26) is an orphan GPCR with constitutive activity, primarily coupling to Gs proteins to increase intracellular cAMP levels. Its endogenous ligand has not been identified, but it is thought to play roles in central nervous system functions. GPR26 is predominantly expressed in the brain, especially in regions such as the cerebral cortex, hippocampus, and amygdala, which are involved in mood regulation, learning, and memory. This brain-specific expression pattern points to a potential role in neuropsychiatric functions. GPR26 is being investigated as a potential pharmacological target in neurological and psychiatric disorders, including anxiety, depression, and epilepsy. Preclinical studies have shown that modulation of GPR26 expression or activity can influence mood and seizure susceptibility. While no selective ligands or drugs are currently available, its expression profile and constitutive signaling make it a candidate for future therapeutic exploration in CNS-related diseases. For more information on GPR26 pharmacology please refer to the IUPHAR database. For further reading refer to:

Davenport AP, Alexander SP, Sharman JL, Pawson AJ, Benson HE, Monaghan AE, Liew WC, Mpamhanga CP, Bonner TI, Neubig RR, Pin JP, Spedding M, Harmar AJ. International Union of Basic and Clinical Pharmacology. LXXXVIII. G protein-coupled receptor list: recommendations for new pairings with cognate ligands. Pharmacol Rev. 2013 May 17;65(3):967-86. doi: 10.1124/pr.112.007179. PMID: 23686350; PMCID: PMC3698937.

Alexander SP, Battey J, Benson HE, Benya RV, Bonner TI, Davenport AP, Dhanachandra Singh K, Eguchi S, Harmar A, Holliday N, Jensen RT, Karnik S, Kostenis E, Liew WC, Monaghan AE, Mpamhanga C, Neubig R, Pawson AJ, Pin JP, Sharman JL, Spedding M, Spindel E, Stoddart L, Storjohann L, Thomas WG, Tirupula K, Vanderheyden P. Class A Orphans in GtoPdb v.2023.1. IUPHAR/BPS Guide to Pharmacology CITE. 2023; 2023(1). Available from: https://doi.org/10.2218/gtopdb/F16/2023.1.

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