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pS473/pS475-β1 (phospho-β1-Adrenoceptor Antibody) Serine473/Serine475 (S473/S475) is a major phosphorylation site of the β1 adrenoceptor. The pS473/pS475-β1 antibody detects phosphorylation in response to high- and low-efficacy agonists but not after PKC activation. S473/S475...
$ 400.00 *
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β1 (GP-IHC-grade), β1-Adrenoceptor Antibody,... The non-phospho- β1 antibody is directed against the carboxyl-terminal tail of human β1 . It can be used to detect total β1 receptors in Western blots independent of phosphorylation. The non-phospho- β1 antibody can also be used to...
$ 400.00 *
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β1 (GP-non-phospho), β1-Adrenoceptor Antibody,... The non-phospho- β1 antibody is directed against the carboxyl-terminal tail of human β1 . It can be used to detect total β1 receptors in Western blots independent of phosphorylation. The non-phospho- β1 antibody can also be used to...
$ 400.00 *
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pS412-β1 (phospho-β1-Adrenoceptor Antibody) Serine412 (S412) is a major phosphorylation site of the β1 adrenoceptor. The pS412-β1 antibody detects phosphorylation in response to high- and low-efficacy agonists but not after PKC activation. S412 phosphorylation is primarily...
$ 400.00 *
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pT404-β1 (phospho-β1-Adrenoceptor Antibody) Threonine404 (T404) is a major phosphorylation site of the β1 adrenoceptor. The pT404-β1 antibody detects phosphorylation in response to high- and low-efficacy agonists but not after PKC activation. T404 phosphorylation is primarily...
$ 400.00 *
NEW
β1 (non-phospho), β1-Adrenoceptor Antibody The non-phospho- β1 antibody is directed against the carboxyl-terminal tail of human β1 . It can be used to detect total β1 receptors in Western blots independent of phosphorylation. The non-phospho- β1 antibody can also be used to...
$ 400.00 *
The β₁-adrenoceptor (β₁-AR) is a G protein–coupled receptor (GPCR) that mediates the effects of catecholamines, primarily noradrenaline and adrenaline, on the cardiovascular system. Pharmacologically, β₁-AR couples mainly to Gs proteins, stimulating adenylate cyclase, which increases cyclic AMP (cAMP) and activates protein kinase A (PKA), leading to enhanced cardiac contractility (inotropy), heart rate (chronotropy), and conduction velocity (dromotropy). It is the principal adrenergic receptor subtype in the heart, especially in ventricular myocytes and the sinoatrial node, although it is also expressed in the kidney (juxtaglomerular cells), where it promotes renin release, and to a lesser extent in the brain. Functionally, β₁-AR activation supports cardiac output and blood pressure regulation during stress or exercise, forming a key component of the sympathetic “fight-or-flight” response. Chronic overstimulation of β₁-AR, however, contributes to cardiac hypertrophy, arrhythmias, and heart failure. Pharmacologically, β₁-selective antagonists (such as metoprolol or bisoprolol) are widely used to treat hypertension, angina, and heart failure by reducing cardiac workload and oxygen demand. Overall, the β₁-adrenoceptor is a critical regulator of cardiac physiology and sympathetic signaling, with major therapeutic importance in cardiovascular medicine. β1-adrenoceptors are regulated by phosphorylation of carboxyl-terminal threonine404 (pT404-ß1), serine412 (pS412-ß1), and serine473/serine475 (pS473/pS475-ß1). This nomenclature refers to the human ß1. In mouse and rat β1-adrenoceptors only serine412 (pS412-ß1) is present. For more information on β1-adrenoceptor pharmacology please refer to the Recently viewed