GPR152 Receptor Antibodies

GPR152 is an orphan class A GPCR for which the endogenous ligand, physiological signaling pathway and pharmacological function remain largely unresolved. The receptor is predominantly expressed in the central nervous system, with detectable expression in several brain regions and particularly in neuronal populations involved in metabolic and neuroendocrine regulation. GPR152 has also been detected in peripheral tissues, although its expression outside the CNS is comparatively poorly characterized. Available studies suggest that the receptor may couple to Gi/o and/or Gq/11 proteins, but these signaling assignments have not been sufficiently validated. Functional evidence indicates that GPR152 may participate in the regulation of neuronal signaling, energy homeostasis and endocrine functions, although a definitive physiological role has not yet been established. Genetic and expression studies have generated interest in GPR152 in the context of metabolic disorders and potentially CNS diseases, but the available evidence remains preliminary. No endogenous ligand has been conclusively identified, and there are currently no well-validated selective agonists or antagonists that can be used as definitive pharmacological tools. No approved drug or clinical-stage therapeutic targeting GPR152 is currently available. Overall, GPR152 represents a highly unexplored orphan GPCR whose ligand discovery and pharmacological characterization could reveal new opportunities for CNS and metabolic drug discovery. For more information on GPR152 pharmacology please refer to the IUPHAR database. For further reading refer to: